Erythrina variegata

• Index
• Plant Species
• Metabolite list (47)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Erythrina variegata
Genus	Erythrina
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Erythrina variegata
Linked NCBI taxonomy ID	3845
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (47)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00009516	6,8-Diprenylgenistein / 8-(gamma,gamma-Dimethylallyl)wighteone / 5,7,4'-Trihydroxy-6,8-diprenylisoflavone	CHEMBL494252		12 / 14 / 11		No. 14	No. 15
C00019741	Eryvarin E / 3-Hydroxy-9-methoxy-2,10-diprenylpterocarpan					No. 14	No. 15
C00018965	Erysubin F	CHEMBL2159045		1 / 0 / 0		No. 14	No. 15
C00010027	Erycristagallin / 3,9-Dihydroxy-2,10-diprenylpterocarpene	CHEMBL462699		1 / 0 / 0		No. 14	No. 15
C00002586	Wighteone / Erythrinin B / 5,7,4'-Trihydroxy-6-prenylisoflavone	CHEMBL393222		2 / 1 / 1		No. 15	No. 15
C00018966	Eryvarin D	CHEMBL1097045				No. 15	No. 15
C00002555	Osajin	CHEMBL238188		36 / 50 / 70		No. 18	No. 15
C00009948	Euchrenone b9					No. 18	No. 15
C00009521	Auriculatin					No. 18	No. 15
C00009514	Scandenone / Warangalone	CHEMBL458134	C105205			No. 18	No. 15
C00018981	(-)-Bidwillon A / 7,2',4'-Trihydroxy-6,8-diprenylisoflavanone					No. 19	No. 14
C00009492	Alpinumisoflavone	CHEMBL238628	C000154	3 / 1 / 1	1 / 0	No. 24	No. 15
C00019381	Bidwillon C / 4'-Hydroxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone	CHEMBL1214836		1 / 1 / 1		No. 24	No. 15
C00009431	Erythrinin A					No. 24	No. 15
C00008197	Isobavachin	CHEMBL491534	C468753		2 / 0	No. 28	No. 14
C00018985	Bidwillon B					No. 39
C00018984	Orientanol F / 2',4'-Dihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavanone					No. 39
C00019725	Eryvarin B / 7,4'-Dihydroxy-5''-(1-hydroxy-1-methylethyl)-8'-prenyl-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':5,6]isoflavone					No. 47	No. 15
C00019069	Erysubin C / (6aR,11aR)-2-Carboxyaldehyde-9-hydroxy-3-methoxypterocarpan					No. 66	No. 15
C00019740	Eryvarin C / (3R)-2',4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavan					No. 135	No. 15
C00002559	Phaseolin / (-)-Phaseollin	CHEMBL448350				No. 135	No. 15
C00009501	Erythrinin C					No. 139
C00019377	Erythrivarone A / 5,4'-Dihydroxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,6]isoflavone					No. 139
C00019738	Eryvarin K / 3,9-Dihydroxy-8-methoxy-4-prenylpterocarpan	CHEMBL1079408		1 / 0 / 0		No. 188	No. 15
C00018899	Orientanol B / 3-O-Methylcalopocarpin	CHEMBL465985				No. 188	No. 15
C00002558	Phaseollidin	CHEMBL508534	C085158	1 / 0 / 0		No. 188	No. 15
C00019739	Eryvarin L / 6,4'-Dihydroxy-2',5'-dimethoxy-2-arybenzofuran					No. 210	No. 15
C00002893	Oxyresveratrol / 2,3,4,5'-Tetrahydroxystilbene	CHEMBL43065		20 / 32 / 49		No. 295	No. 13
C00002515	Cristacarpin / Erythrabyssin I	CHEMBL454849	C085157	2 / 1 / 1		No. 325	No. 15
C00019724	Eryvarin A / (6aS,11aS,5'S)-3,6a,5'-Trihydroxy-6',6'-dimethyl-4',5'-dihydropyrano[2',3':9,10]pterocarpan	CHEMBL269337				No. 325	No. 15
C00009664	Folitenol	CHEMBL551155		1 / 0 / 0		No. 352	No. 15
C00018967	Orientanol C					No. 352	No. 15
C00018947	Bidwillol A					No. 400
C00019735	Eryvarin H / 7,4'-Dihydroxy-2',5'-dimethoxyisoflav-3-ene					No. 400
C00018969	Sigmoidin K / 3,9-Dihydroxy-2,10-diprenylcoumestan	CHEMBL1095262	C090620			No. 436	No. 17
C00027356	Erythrartine / (+)-Erythrartine / 11-Hydroxyerysotrine	CHEMBL217996				No. 446	No. 4
C00010024	2-Prenyl-6a-hydroxyphaseollidin / 3,6a,9-Trihydroxy-2,10-diprenylpterocarpan					No. 460
C00009669	Erythrabyssin II / 3,9-Dihydroxy-2,10-diprenylpterocarpan	CHEMBL455372		1 / 0 / 0		No. 460
C00018930	Erystagallin A	CHEMBL1088462		1 / 0 / 0		No. 460
C00019737	Eryvarin J / 3,9-Dihydroxy-2,4-diprenylpterocarpan					No. 460
C00019378	Erythrivarone B					No. 724
C00000615	Caffeic acid	CHEMBL145 CHEMBL1320034		68 / 64 / 63		No. 904	No. 6
C00019068	Laburnetin / 5,7,4',2''-Tetrahydroxy-6-[3''-methyl-3''-butenyl]isoflavone					No. 984
C00020453	Eryvariestyrene					No. 1271	No. 13
C00019736	Eryvarin I / 3-Hydroxy-2'-methoxy-6'',6''-dimethylpyrano[2'',3'':4',3']isoflav-3-ene					No. 2189
C00002074	Stachydrine	CHEMBL394450 CHEMBL1456892 CHEMBL1986864		10 / 8 / 12		No. 2627	No. 1
C00001854	beta-Erythroidine		C004873			No. 4287	No. 4

Human Protein / Gene in interactions

100 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000615 C00002558 C00009492 C00009664 C00009669 C00018930 C00018965 C00019738	0 / 0
P03372	Estrogen receptor	NR3A1	C00000615 C00002515 C00002586 C00009492 C00019381	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00000615 C00002555 C00002893 C00009516	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000615 C00002074 C00002555	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000615 C00002074 C00002555	1 / 2
Q92731	Estrogen receptor beta	NR3A2	C00002515 C00002586 C00009492	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000615 C00002074 C00002893	0 / 0
O00255	Menin	Unclassified protein	C00000615 C00002074 C00002555	2 / 5
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002555 C00002893 C00009516	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000615 C00002555 C00009516	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000615 C00002555 C00009516	4 / 3
P14780	Matrix metalloproteinase-9	M10A	C00000615 C00002893	2 / 2
P06746	DNA polymerase beta	Enzyme	C00000615 C00002555	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002555 C00009516	6 / 4
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000615 C00002555	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002555 C00009516	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000615 C00002555	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000615 C00002555	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000615 C00002893	0 / 3
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002555 C00009516	2 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000615 C00002555	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002555 C00009516	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000615 C00002074	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00000615 C00002555	11 / 10
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000615 C00002555	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000615 C00002074	3 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002893 C00009516	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00000615 C00002893	1 / 3
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00002555 C00009516	0 / 3
P04637	Cellular tumor antigen p53	Transcription Factor	C00002555 C00002893	7 / 37
P14679	Tyrosinase	Oxidoreductase	C00000615 C00002893	4 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000615 C00002074	0 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002074 C00002555	0 / 0
P03956	Interstitial collagenase	M10A	C00000615 C00002893	0 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000615 C00002893	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002555 C00009516	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000615 C00002074	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000615 C00002555	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002555 C00002893	2 / 2
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002555 C00002893	4 / 2
O75496	Geminin	Unclassified protein	C00002555 C00009516	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002555 C00002893	1 / 1
Q8TDS4	Hydroxycarboxylic acid receptor 2	Hydroxycarboxylic acid receptor	C00000615	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002074	0 / 0
P42858	Huntingtin	Unclassified protein	C00002555	1 / 1
P42330	Aldo-keto reductase family 1 member C3	Enzyme	C00000615	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000615	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00000615	1 / 2
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000615	0 / 0
P15121	Aldose reductase	Enzyme	C00000615	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00000615	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00000615	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000615	1 / 8
Q9Y253	DNA polymerase eta	Enzyme	C00002555	1 / 1
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002555	0 / 0
Q9GZT9	Egl nine homolog 1	Enzyme	C00000615	1 / 1
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00000615	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00002893	4 / 4
P06280	Alpha-galactosidase A	Enzyme	C00000615	1 / 1
P45452	Collagenase 3	M10A	C00002893	1 / 1
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00000615	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00002893	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000615	1 / 2
Q16790	Carbonic anhydrase 9	Lyase	C00000615	0 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00000615	3 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000615	3 / 3
Q04828	Aldo-keto reductase family 1 member C1	Enzyme	C00000615	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000615	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000615	5 / 2
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000615	1 / 1
P37840	Alpha-synuclein	Unclassified protein	C00002893	4 / 2
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000615	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002555	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002555	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002555	0 / 0
P39900	Macrophage metalloelastase	M10A	C00002893	0 / 0
P52895	Aldo-keto reductase family 1 member C2	Enzyme	C00000615	1 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00000615	4 / 2
P43166	Carbonic anhydrase 7	Lyase	C00000615	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000615	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000615	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00000615	0 / 0
P08254	Stromelysin-1	M10A	C00002893	1 / 0
P04054	Phospholipase A2	Enzyme	C00010027	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00000615	1 / 1
Q12794	Hyaluronidase-1	Enzyme	C00000615	1 / 2
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00000615	3 / 0
P24298	Alanine aminotransferase 1	Enzyme	C00000615	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000615	0 / 0
O00167	Eyes absent homolog 2	Enzyme	C00002555	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000615	2 / 2
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000615	1 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000615	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00000615	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002555	4 / 1
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00000615	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00000615	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00000615	0 / 0
P17516	Aldo-keto reductase family 1 member C4	Enzyme	C00000615	1 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00002555	1 / 0

3 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00009492
5241	PGR, NR3C3, PR	progesterone receptor	C00008197
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00008197

Related Diseases

Diseases related to proteins in ChEMBL interactions