KEGG   PATHWAY: mmu05010
Entry
mmu05010                    Pathway                                
Name
Alzheimer disease - Mus musculus (house mouse)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmu05010  Alzheimer disease
mmu05010

Disease
H00056  Alzheimer disease
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
100504663  Atg14; autophagy related 14 [KO:K17889]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
105675  Ppif; peptidylprolyl isomerase F (cyclophilin F) [KO:K09565] [EC:5.2.1.8]
106947  Slc39a3; solute carrier family 39 (zinc transporter), member 3 [KO:K14709]
106957  Slc39a6; solute carrier family 39 (metal ion transporter), member 6 [KO:K14712]
108071  Grm5; glutamate receptor, metabotropic 5 [KO:K04604]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
11441  Chrna7; cholinergic receptor, nicotinic, alpha polypeptide 7 [KO:K04809]
11487  Adam10; a disintegrin and metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
11491  Adam17; a disintegrin and metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
115487111  Gm29667; predicted gene 29667 [KO:K00134] [EC:1.2.1.12]
11596  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
11785  Apbb1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
11789  Apc; APC, WNT signaling pathway regulator [KO:K02085]
11816  Apoe; apolipoprotein E [KO:K04524]
11820  App; amyloid beta precursor protein [KO:K04520]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
11911  Atf4; activating transcription factor 4 [KO:K04374]
11937  Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:7.2.2.10]
11938  Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:7.2.2.10]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
12005  Axin1; axin 1 [KO:K02157]
12006  Axin2; axin 2 [KO:K04385]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12288  Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
12292  Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12333  Capn1; calpain 1 [KO:K01367] [EC:3.4.22.52]
12334  Capn2; calpain 2 [KO:K03853] [EC:3.4.22.53]
12364  Casp12; caspase 12 [KO:K04741] [EC:3.4.22.-]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
12369  Casp7; caspase 7 [KO:K04397] [EC:3.4.22.60]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12387  Ctnnb1; catenin beta 1 [KO:K02105]
12421  Rb1cc1; RB1-inducible coiled-coil 1 [KO:K17589]
12568  Cdk5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
12569  Cdk5r1; cyclin dependent kinase 5, regulatory subunit 1 [KO:K11716]
12669  Chrm1; cholinergic receptor, muscarinic 1, CNS [KO:K04129]
12671  Chrm3; cholinergic receptor, muscarinic 3, cardiac [KO:K04131]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
12977  Csf1; colony stimulating factor 1 (macrophage) [KO:K05453]
12995  Csnk2a1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
13000  Csnk2a2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
13001  Csnk2b; casein kinase 2, beta polypeptide [KO:K03115]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
13198  Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
13380  Dkk1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
13542  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
13543  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
13544  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
13665  Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
13666  Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
14082  Fadd; Fas associated via death domain [KO:K02373]
14102  Fas; Fas cell surface death receptor [KO:K04390]
14296  Frat1; frequently rearranged in advanced T cell lymphomas [KO:K03069]
14362  Fzd1; frizzled class receptor 1 [KO:K02432]
14365  Fzd3; frizzled class receptor 3 [KO:K02329]
14366  Fzd4; frizzled class receptor 4 [KO:K02354]
14367  Fzd5; frizzled class receptor 5 [KO:K02375]
14368  Fzd6; frizzled class receptor 6 [KO:K02376]
14369  Fzd7; frizzled class receptor 7 [KO:K02432]
14370  Fzd8; frizzled class receptor 8 [KO:K02375]
14371  Fzd9; frizzled class receptor 9 [KO:K02842]
14433  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14810  Grin1; glutamate receptor, ionotropic, NMDA1 (zeta 1) [KO:K05208]
14811  Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209]
14812  Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210]
14813  Grin2c; glutamate receptor, ionotropic, NMDA2C (epsilon 3) [KO:K05211]
14814  Grin2d; glutamate receptor, ionotropic, NMDA2D (epsilon 4) [KO:K05212]
14977  Slc39a7; solute carrier family 39 (zinc transporter), member 7 [KO:K14713]
15108  Hsd17b10; hydroxysteroid (17-beta) dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
15925  Ide; insulin degrading enzyme [KO:K01408] [EC:3.4.24.56]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16175  Il1a; interleukin 1 alpha [KO:K04383]
16176  Il1b; interleukin 1 beta [KO:K04519]
16193  Il6; interleukin 6 [KO:K05405]
16333  Ins1; insulin I [KO:K04526]
16334  Ins2; insulin II [KO:K04526]
16337  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
16367  Irs1; insulin receptor substrate 1 [KO:K16172]
16369  Irs3; insulin receptor substrate 3 [KO:K17445]
16370  Irs4; insulin receptor substrate 4 [KO:K17446]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
16572  Kif5a; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
16573  Kif5b; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
16574  Kif5c; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
16593  Klc1; kinesin light chain 1 [KO:K10407]
16594  Klc2; kinesin light chain 2 [KO:K10407]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
16956  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
16971  Lrp1; low density lipoprotein receptor-related protein 1 [KO:K04550]
16973  Lrp5; low density lipoprotein receptor-related protein 5 [KO:K03068]
16974  Lrp6; low density lipoprotein receptor-related protein 6 [KO:K03068]
17380  Mme; membrane metallo endopeptidase [KO:K01389] [EC:3.4.24.11]
17463  Psmd7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [KO:K03038]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
17711  CYTB; cytochrome b [KO:K00412]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
17762  Mapt; microtubule-associated protein tau [KO:K04380]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
18174  Slc11a2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 [KO:K21398]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
19106  Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
19164  Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
19165  Psen2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
19166  Psma2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
19167  Psma3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
19170  Psmb1; proteasome (prosome, macropain) subunit, beta type 1 [KO:K02732] [EC:3.4.25.1]
19172  Psmb4; proteasome (prosome, macropain) subunit, beta type 4 [KO:K02736] [EC:3.4.25.1]
19173  Psmb5; proteasome (prosome, macropain) subunit, beta type 5 [KO:K02737] [EC:3.4.25.1]
19175  Psmb6; proteasome (prosome, macropain) subunit, beta type 6 [KO:K02738] [EC:3.4.25.1]
19177  Psmb7; proteasome (prosome, macropain) subunit, beta type 7 [KO:K02739] [EC:3.4.25.1]
19179  Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
19181  Psmc2; proteasome (prosome, macropain) 26S subunit, ATPase 2 [KO:K03061]
19182  Psmc3; proteasome (prosome, macropain) 26S subunit, ATPase 3 [KO:K03065]
19184  Psmc5; protease (prosome, macropain) 26S subunit, ATPase 5 [KO:K03066]
19185  Psmd4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [KO:K03029]
19225  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
20168  Rtn3; reticulon 3 [KO:K20723]
20192  Ryr3; ryanodine receptor 3 [KO:K04963]
20422  Sem1; SEM1, 26S proteasome complex subunit [KO:K10881]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
20617  Snca; synuclein, alpha [KO:K04528]
208117  Aph1b; aph1 homolog B, gamma secretase subunit [KO:K06172]
20890  Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
212398  Frat2; frequently rearranged in advanced T cell lymphomas 2 [KO:K03096]
213053  Slc39a14; solute carrier family 39 (zinc transporter), member 14 [KO:K14720]
213788  Chrm5; cholinergic receptor, muscarinic 5 [KO:K04133]
214922  Slc39a2; solute carrier family 39 (zinc transporter), member 2 [KO:K14709]
215999  Mcu; mitochondrial calcium uniporter [KO:K20858]
216795  Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
21762  Psmd2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [KO:K03028]
21926  Tnf; tumor necrosis factor [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
22123  Psmd3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [KO:K03033]
22142  Tuba1a; tubulin, alpha 1A [KO:K07374]
22143  Tuba1b; tubulin, alpha 1B [KO:K07374]
22144  Tuba3a; tubulin, alpha 3A [KO:K07374]
22145  Tuba4a; tubulin, alpha 4A [KO:K07374]
22146  Tuba1c; tubulin, alpha 1C [KO:K07374]
22147  Tuba3b; tubulin, alpha 3B [KO:K07374]
22151  Tubb2a; tubulin, beta 2A class IIA [KO:K07375]
22152  Tubb3; tubulin, beta 3 class III [KO:K07375]
22153  Tubb4a; tubulin, beta 4A class IVA [KO:K07375]
22154  Tubb5; tubulin, beta 5 class I [KO:K07375]
22241  Ulk1; unc-51 like kinase 1 [KO:K21357] [EC:2.7.11.1]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
22408  Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22409  Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22410  Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22411  Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
22412  Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22413  Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
22423  Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
22433  Xbp1; X-box binding protein 1 [KO:K09027]
225326  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
226548  Aph1a; aph1 homolog A, gamma secretase subunit [KO:K06172]
226641  Atf6; activating transcription factor 6 [KO:K09054]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
227059  Slc39a10; solute carrier family 39 (zinc transporter), member 10 [KO:K14716]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
227613  Tubb4b; tubulin, beta 4B class IVB [KO:K07375]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
228361  Ambra1; autophagy/beclin 1 regulator 1 [KO:K17985]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
232943  Klc3; kinesin light chain 3 [KO:K10407]
234130  Dkk4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
234664  Nae1; NEDD8 activating enzyme E1 subunit 1 [KO:K04532]
237038  Nox1; NADPH oxidase 1 [KO:K08008]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
23805  Apc2; APC regulator of WNT signaling pathway 2 [KO:K02085]
23821  Bace1; beta-site APP cleaving enzyme 1 [KO:K04521] [EC:3.4.23.46]
238463  Tubal3; tubulin, alpha-like 3 [KO:K07374]
23996  Psmc4; proteasome (prosome, macropain) 26S subunit, ATPase, 4 [KO:K03063]
23997  Psmd13; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [KO:K03039]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26400  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26440  Psma1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
26441  Psma4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
26442  Psma5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
26443  Psma6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
26444  Psma7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
26445  Psmb2; proteasome (prosome, macropain) subunit, beta type 2 [KO:K02734] [EC:3.4.25.1]
26446  Psmb3; proteasome (prosome, macropain) subunit, beta type 3 [KO:K02735] [EC:3.4.25.1]
27373  Csnk1e; casein kinase 1, epsilon [KO:K08960] [EC:2.7.11.1]
27412  Peg12; paternally expressed 12 [KO:K03069]
277468  Slc39a12; solute carrier family 39 (zinc transporter), member 12 [KO:K14718]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
29869  Ulk2; unc-51 like kinase 2 [KO:K08269] [EC:2.7.11.1]
30791  Slc39a1; solute carrier family 39 (zinc transporter), member 1 [KO:K14709]
328133  Slc39a9; solute carrier family 39 (zinc transporter), member 9 [KO:K14715]
329015  Atg2a; autophagy related 2A [KO:K17906]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
384783  Irs2; insulin receptor substrate 2 [KO:K07187]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
494124  Calm5; calmodulin 5 [KO:K02183]
50490  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
51897  Atg13; autophagy related 13 [KO:K08331]
52639  Wipi1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
53313  Atp2a3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:7.2.2.10]
53857  Tuba8; tubulin, alpha 8 [KO:K07374]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
545486  Tubb1; tubulin, beta 1 class VI [KO:K07375]
54652  Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853]
56175  Bace2; beta-site APP-cleaving enzyme 2 [KO:K07747] [EC:3.4.23.45]
56208  Becn1; beclin 1, autophagy related [KO:K08334]
56436  Adrm1; adhesion regulating molecule 1 26S proteasome ubiquitin receptor [KO:K06691]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
56811  Dkk2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
57265  Fzd2; frizzled class receptor 2 [KO:K02235]
57296  Psmd8; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [KO:K03031]
59029  Psmd14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [KO:K03030]
59287  Ncstn; nicastrin [KO:K06171]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
641340  Nrbf2; nuclear receptor binding factor 2 [KO:K21246]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
66340  Psenen; presenilin enhancer gamma secretase subunit [KO:K06170]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
66413  Psmd6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [KO:K03037]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
66445  Cyc1; cytochrome c-1 [KO:K00413]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
66997  Psmd12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [KO:K03035]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
67089  Psmc6; proteasome (prosome, macropain) 26S subunit, ATPase, 6 [KO:K03064]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
67151  Psmd9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [KO:K06693]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
67547  Slc39a8; solute carrier family 39 (metal ion transporter), member 8 [KO:K14714]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
67738  Ppid; peptidylprolyl isomerase D (cyclophilin D) [KO:K05864] [EC:5.2.1.8]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
67951  Tubb6; tubulin, beta 6 class V [KO:K07375]
68118  Atg101; autophagy related 101 [KO:K19730]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
68318  Aph1c; aph1 homolog C, gamma secretase subunit [KO:K06172]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
68427  Slc39a13; solute carrier family 39 (metal ion transporter), member 13 [KO:K14719]
68585  Rtn4; reticulon 4 [KO:K20720]
69077  Psmd11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [KO:K03036]
69806  Slc39a11; solute carrier family 39 (metal ion transporter), member 11 [KO:K14717]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
70247  Psmd1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [KO:K03032]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
70405  Calml3; calmodulin-like 3 [KO:K02183]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
72002  Slc39a5; solute carrier family 39 (metal ion transporter), member 5 [KO:K14711]
72027  Slc39a4; solute carrier family 39 (zinc transporter), member 4 [KO:K14710]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
73677  Psma8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
73710  Tubb2b; tubulin, beta 2B class IIB [KO:K07375]
74764  Klc4; kinesin light chain 4 [KO:K10407]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
74781  Wipi2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
75600  Calml4; calmodulin-like 4 [KO:K02183]
75669  Pik3r4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
76559  Atg2b; autophagy related 2B [KO:K17906]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
78943  Ern1; endoplasmic reticulum to nucleus signalling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
80796  Calm4; calmodulin 4 [KO:K02183]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
93687  Csnk1a1; casein kinase 1, alpha 1 [KO:K08957] [EC:2.7.11.1]
93735  Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
93897  Fzd10; frizzled class receptor 10 [KO:K02842]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
mmu00190  Oxidative phosphorylation
mmu03050  Proteasome
mmu04020  Calcium signaling pathway
mmu04140  Autophagy - animal
mmu04141  Protein processing in endoplasmic reticulum
mmu04210  Apoptosis
mmu04310  Wnt signaling pathway
mmu04910  Insulin signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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